Indian Journal of Private Psychiatry

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VOLUME 16 , ISSUE 1 ( January-June, 2022 ) > List of Articles

CASE REPORT

Atypical Psychiatric Manifestation of Primary Wilson's Disease: A Case Report

M Subramanyam, Sanjiv Chamraj, Khushboo Dewani, Preeti Srinivasa

Keywords : Bipolar affective disorder, Extrapyramidal side effects, Irritability, Rigidity, Tremors

Citation Information : Subramanyam M, Chamraj S, Dewani K, Srinivasa P. Atypical Psychiatric Manifestation of Primary Wilson's Disease: A Case Report. Ind J Priv Psychiatry 2022; 16 (1):34-37.

DOI: 10.5005/jp-journals-10067-0096

License: CC BY-NC 4.0

Published Online: 16-03-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Background: Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism. It is associated with ATP7B gene mutations, present on chromosome 13. It is primarily a liver disease, but presentation varies according to copper deposition in various organs. The diagnosis depends on clinical features, Kayser–Fleischer rings, biochemical parameters, radiological findings, liver biopsy, and gene analysis. Case: We report an atypical presentation of WD, where the patient presented with only psychiatric manifestations with two episodes of mania with duration of 3 years to evolve from psychiatric manifestations to neurological and hepatic manifestations of WD. Conclusion: A high index of suspicion is required, and early recognition of atypical presentation and initiation of the treatment can prevent a catastrophic outcome.


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