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VOLUME 18 , ISSUE 1 ( January-June, 2024 ) > List of Articles

Original Article

Association between Severity of Depression and CRP Level: A Cross-sectional Study

Julia Keisham, Vidya Sanapala, Niveditha Vasireddy, Ramya Spandana Tata, Srikrishna Nukala, Srinivas Singisetti, Abhilash Garapati

Keywords : C-reactive protein, CRP, Cross-sectional observational, Depression, Inflammatory markers, Severity of depression, Suicidal ideation

Citation Information : Keisham J, Sanapala V, Vasireddy N, Tata RS, Nukala S, Singisetti S, Garapati A. Association between Severity of Depression and CRP Level: A Cross-sectional Study. Ind J Priv Psychiatry 2024; 18 (1):4-8.

DOI: 10.5005/jp-journals-10067-0167

License: CC BY-NC 4.0

Published Online: 03-01-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Aim and background: Depression is a worldwide mental health issue. Depression is believed to result from multifaceted social, psychological, and biological interactions. Many recent studies have found elevated levels of pro-inflammatory cytokines in patients with depression and speculated on their involvement in the pathophysiology of depression. The autonomic nervous system (ANS) activity and hypothalamic (HPA) axis are linked to depression symptoms and C-reactive protein (CRP) production. So, this study aimed to study the severity of depression (SOD) and its correlation to serum CRP levels and identify the relationship between suicidal ideations and CRP levels. Materials and methods: This is a cross-sectional study, hospital-based on patients diagnosed with depression who attended the outpatient department, fulfilled the inclusion criteria, and gave consent. A semi-structured proforma for sociodemographic details and the Montgomery-Asberg Depression Rating Scale to assess the SOD were applied to the patients, after which serum C-reactive protein levels (CRP) were tested based on the particle-enhanced turbidimetric immunoassay (PETIA) technique. Results and conclusion: In our study, we found a statistically significant (p-value of 0.001) positive correlation between the SOD and serum CRP levels. A statistically significant (p-value = 0.001) association is found between the presence of suicidal ideations and an increase in CRP levels. In conclusion, with the SOD and the presence of suicidal ideations, higher CRP levels were observed. Clinical significance: These results indicate that CRP levels can be an essential marker for understanding the disease pathophysiology and may contribute to therapeutic management in the future.

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