Introduction: Lesions of the splenium of the corpus callosum (SCC) are nowadays seen in a wide variety of medical conditions due to the increasing usage of magnetic resonance imaging (MRI). These lesions can be either reversible or irreversible depending on the etiology. However, in cases of epilepsy, they are called transient as they have been observed to resolve spontaneously after a period of time and this transient nature can be detected in its distinguishing features on MRI that differentiates it from other medical conditions. Case proper: The case is about a 22-year-old male previously diagnosed with Generalized tonic-clonic seizure for the last 15 years who presented to casualty with irritability and aggressive behavior. On further evaluation, it was revealed that he had been taking antiepileptic drugs (AEDs) for the last 7 months and had suddenly stopped them. Magnetic resonance imaging revealed a transient focal cytotoxic lesion in the corpus callosum. Later both psychotic behavior and seizures were controlled and MRI during follow-up showed resolution of the focal lesion. Conclusion: The classical findings in this patient with a history of epilepsy with sudden antiepileptic stoppage followed by behavioral symptoms along with an MRI showing a transient focal lesion in the corpus callosum of splenium with spontaneous resolution on follow-up are indicative of a favorable prognosis, which can be used to differentiate it from other medical conditions where splenial lesions are also found.