Atypical antipsychotics are known to cause cardiovascular side effects, such as prolonging the QTc interval due to blockade of the potassium repolarization channels, and hence they predispose to ventricular arrhythmias, like premature ventricular complexes (PVCs). Here, we report a case of a male schizophrenic patient who is complaining of palpitations and feeling clinically as well as symptomatically troublesome PVCs associated with risperidone. We consider that PVCs may have been generated by risperidone, with his stressful mental condition, and subsided after withholding it.
Ahn MS. Current concepts of premature ventricular contractions. J Lifestyle Med 2013;3(1):26–33. PMID: 26064834.
Sicouri S, Antzelevitch C. Sudden cardiac death secondary to antidepressant and antipsychotic drugs. Expert Opin Drug Saf 2008;7(2):181–194. DOI: 10.1517/14740322.214.171.124.
Ataklte F, Erqou S, Laukkanen J, et al. Meta-analysis of ventricular premature complexes and their relation to cardiac mortality in general populations. Am J Cardiol 2013;112(8):1263–1270. DOI: 10.1016/j.amjcard.2013.05.065.
Achalia R, Andrade C. Ventricular premature contractions associated with iloperidone. Indian J Psychiatry 2013;55(2):195–160. DOI: 10.4103/0019-5545.111464.
Shao Q, Quan W, Jia X, et al. Severe arrhythmia induced by orally disintegrating aripiprazole tablets (Bosiqing®): a case report. Neuropsychiatr Dis and Treat 2015;11(1):3019–3021. DOI: 10.2147/NDT.S91771.
Goyal RS, Goyal SB. Symptomatic bradyarrhythmia secondary to risperidone (letter). Am J Psychiatry 2003;160(12):2243. DOI: 10.1176/appi.ajp.160.12.2243.
Fayek M, Kingsbury SJ, Zada J, et al. Psychopharmacology: cardiac effects of antipsychotic medications. Psychiatr Serv 2001;52(5): 607–609. DOI: 10.1176/appi.ps.52.5.607.
Deguchi A, Nakamura M, Hayashi T, et al. Quetiapine-induced frequent premature ventricular contraction. Gen Hosp Psychiatry 2012;34(2):211.e1–211.e3. DOI: 10.1016/j.genhosppsych.2011.11.003.
Magyar J, Banyasz T, Bagi Z, et al. Electrophysiological effects of risperidone in mammalian cardiac cells. Naunyn Schmiedebergs Arch Pharmacol 2002;366(4):350–356. DOI: 10.1007/s00210-002-0595-1.
Kopala LC, Day C, Dillman B, et al. A case of risperidone overdose in early schizophrenia: a review of potential complications. J Psychiatry Neurosci 1998;23(5):305–208. PMID: 9846036.
Stefatos A, Ha JN, Baranchuk A, et al. Atrial fibrillation and injected aripiprazole: a case report. Innov Clin Neurosci 2028;15(5–6):43–45. PMID: 30013819.