Many journals and other published guidelines provide large, sometimes strict instructions to be included for becoming eligible in academic journals. However, there is a lack of simple and clear recommendations on how to write such scientific articles. We propose a simple and easy-to-follow hypothesis-based approach. The introduction section should start by introducing the relevant concepts, formulate the study hypothesis, mention the gap in knowledge in the existing literature, and describing the study hypothesis in simple language at the end. The material and methods section must describe the study design, sample or material, the tools, instruments, inclusion and exclusion criteria, and procedures used to test the study hypothesis. The results section must describe the data analyses that lead to the confirmation or rejection of the hypothesis. The discussion must state whether the study hypothesis has been confirmed or rejected and compare the study result with previous research. It should clarify the limitations of the study and explore the relevance of the study findings for clinical practice and future research. An abstract at the beginning of the manuscript, usually structured with objectives, material and methods, results and conclusion, should be added. Acknowledgments, ethical approval, informed consent by study subjects, conflicts of interests by authors, and a reference list will be needed in most scientific journals.