Citation Information :
Kumar P, Sangma RD, Nerli LM, Vasavada DA, Mayani KM, Tiwari DS. Knowledge, Attitude, and Beliefs Regarding Convalescent Plasma Donation among COVID-19-recovered Patients at a Tertiary Care Center in India. Ind J Priv Psychiatry 2020; 14 (2):80-84.
Background: Convalescent plasma is gathered from a possible human source of specific antibodies. Convalescent plasma is released as an “off-label” therapy for novel coronavirus 2019 (COVID-19). Amid the national shortage of this blood product, it is critically important that those who have recovered from COVID-19 donate plasma.
Aim: The current study aimed to assess the knowledge and attitude of COVID-19 recovered patients toward convalescent plasma donation.
Method: A cross-sectional study was carried out among patients discharged after recovery from COVID-19 at a tertiary care center from August 2020 to December 2020. Participants were approached 30 to 45 days after discharge from the hospital and requested to complete a semi-structured pro forma containing the following sections: (1) Demographic details; (2) Knowledge about Convalescent Plasma Questionnaire; (3) Attitude toward Convalescent Plasma Questionnaire; and (4) Reasons for not donating plasma. Following this, education was given to participants about plasma donation.
Result: A total of 400 participants were included in the study of age 18 to 60 years, out of them 42.75% donated plasma and 57.25% did not donate. Participants have good knowledge about their blood group, the requirement of blood group matching for plasma donation, and the use of convalescent plasma therapy. Plasma donors have a more positive attitude toward donation. Among non-donors, 47.8% of participants were unaware, while 42% did not know about fitness for plasma donation. Non-donors have the misbelief that plasma donation temporarily weakened the individual and those who donate plasma can contract a disease. Slight negative correlation between “knowledge” and “attitude” toward plasma donation’ scores on the “Pearson correlation test” (r = 0−0.142, p = 0.005).
Conclusion: Donors have a more positive attitude toward plasma donation. The idea of voluntary plasma donation can be intensively promoted by improving knowledge and awareness through education and specific campaigns.
Bakhtawar N, Usman M, Khan MMU. Convalescent plasma therapy and its effects on COVID-19 patient outcomes: a systematic review of current literature. Cureus 2020;12(8):e9535. DOI: 10.7759/cureus.9535.
Marano G, Vaglio S, Pupella S, et al. Convalescent plasma: new evidence for an old therapeutic tool? Blood Transfus 2016;14(2):152–157. DOI: 10.2450/2015.0131-15.
Griensven JV, Edwards T, de Lamballerie X, et al. Evaluation of convalescent plasma for Ebola virus disease in Guinea. New Engl J Med 2016;374(1):33–42. DOI: 10.1056/NEJMoa1511812.
Hung IF, To KK, Lee CK, et al. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection. Clin Infect Dis 2011;52(4):447–456. DOI: 10.1093/cid/ciq106.
The WHO MERS-CoV Research Group. State of knowledge and data gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in humans. PLoS Curr 2013;5:ecurrents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8. DOI: 10.1371/currents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8.
Lai ST. Treatment of severe acute respiratory syndrome. Eur J Clin Microbiol Infect Dis. 2005 Sep;24(9):583–591. DOI: 10.1007/s10096-005-0004-z.
Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients with novel coronavirus disease 2019. Clin Infect Dis 2020;71(16):2027–2034. DOI: 10.1093/cid/ciaa344.
Chen L, Xiong J, Bao L, et al. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis 2020;20(4):398–400. DOI: 10.1016/S1473-3099(20)30141-9.
Cheng Y, Wong R, Soo YOY, et al. Use of convalescent plasma therapy in SARS patients in Hong Kong. Eur J Clin Microbiol Infect Dis 2005;24(1):44–46. DOI: 10.1007/s10096-004-1271-9.
Gopal BM. Need for more awareness on plasma donation, say doctors. The Hindu. 2020. Available from: https://www.thehindu.com/news/cities/Visakhapatnam/need-for-more-awareness-on-plasma-donation-say-doctors/article32537383.ece.
American Red Cross. Convalescent plasma shortage: virus survivors urged to donate plasma to help patients. 2021. Available from: https://www.redcross.org/about-us/news-and-events/news/2020/covid-19-survivors-urged-to-donate-plasma-to-help-those-battling-coronavirus.html.
Perenc L, Pęczkowski R. Knowledge and attitudes of young adults towards donation of COVID-19 convalescent plasma and its therapeutic properties. Research Square 2021. DOI:10.21203/rs.3.rs-286651/v1.
Chauhan R, Kumar R, Thakur S. A study to assess the knowledge, attitude, and practices about blood donation among medical students of a medical college in North India. J Family Med Prim Care 2018;7(4):693–697. DOI: 10.4103/jfmpc.jfmpc_54_17.
Saeed S. Knowledge, Attitude and practice of plasma donation among COVID-19 recovered patients in Punjab, Pakistan: a cross-sectional study. Microbiol Current Res 2021;0(0):10–10. [cited on 30 March 2021]. Available from: https://epidemiology-public health.conference series.com/.
Beyene GA. Voluntary blood donation knowledge, attitudes, and practices in Central Ethiopia. IJGM 2020;13:67–76. DOI: 10.2147/IJGM.S246138.
Wiwanitkit V. Knowledge about blood donation among a sample of Thai university students. Vox Sanguinis 2002;83:97–99. DOI: 10.1046/j.1423-0410.2002.00209.x.
Dubey A, Sonker A, Chaurasia R, et al. Knowledge, attitude and beliefs of people in North India regarding blood donation. Blood Transfus 2014;12(Suppl. 1):s21–s27. DOI: 10.2450/2012.0058-12.
Schlumpf KS, Glynn SA, Schreiber GB, et al. Factors influencing donor return. Transfusion 2008;48(2):264–272. DOI: 10.1111/j.1537-2995.2007.01519.x.
Shenga N, Pal R, Sengupta S. Behavior disparities towards blood donation in Sikkim, India. Asian J Transfus Sci 2008;2(2):56–60. DOI: 10.4103/0973-6247.42692.
Boulware LE, Ratner LE, Ness PM, et al. The contribution of sociodemographic, medical, and attitudinal factors to blood donation among the general public. Transfusion 2002;42(6):669–678. DOI: 10.1046/j.1537-2995.2002.00120.x.
Glynn SA, Williams AE, Nass CC, et al. Attitudes toward blood donation incentives in the United States: implications for donor recruitment. Transfusion 2003;43(1):7–16. DOI: 10.1046/j.1537-2995.2003.00252.x.