Indian Journal of Private Psychiatry

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  14 (2020)
Volume  13 (2019)
Volume  12 (2018)
Volume  11 (2017)
Related articles

VOLUME 13 , ISSUE 2 ( July-December, 2019 ) > List of Articles

CASE REPORT

Trihexyphenidyl-induced Hypersexuality: A Case Report

Keywords : Hypersexuality, Trihexyphenidyl,Anticholinergics

Citation Information : Trihexyphenidyl-induced Hypersexuality: A Case Report. Ind J Priv Psychiatry 2019; 13 (2):87-88.

DOI: 10.5005/jp-journals-10067-0040

License: CC BY-NC 4.0

Published Online: 00-12-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Anticholinergics such as trihexyphenidyl are widely prescribed for the prophylaxis and treatment of antipsychotic-induced extrapyramidal symptoms. Although prescribed commonly with the typical antipsychotics, they may also be prescribed to counteract the extrapyramidal side effects of atypical antipsychotics rarely. These drugs may sometimes cause euphoria as a side effect. We report a case of a 29-year-old male suffering from schizophrenia who developed features of hypersexuality on starting trihexyphenidyl, which resolved on its discontinuation only to re-emerge on re-challenging the patient with the same drug.

PDF Share
  1. Barnes TR, McPhillips MA. Antipsychotic-induced extrapyramidal symptoms. CNS Drugs 1996;6(4):315–330. DOI: 10.2165/00023210-199606040-00006.
  2. Casey DE. Neuroleptic-induced acute extrapyramidal syndromes and tardive dyskinesia. Psychiatr Clin 1993;16(3):589–610. DOI: 10.1016/S0193-953X(18)30166-7.
  3. Robottom BJ, Reich SG. Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review. The Neurologist 2011;17(6):340–341. DOI: 10.1097/NRL.0b013e31822b54d2.
  4. Veselinović T, Vernaleken I, Janouschek H, et al. Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers. Psychopharmacology 2015;232(9):1607–1617. DOI: 10.1007/s00213-014-3794-9.
  5. Tani M, Akashi N, Hori K, et al. Anticholinergic activity and schizophrenia. Neurodegen Dis 2015;15(3):168–174. DOI: 10.1159/000381523.
  6. Ramasubbu R. Antidepressant treatment-associated behavioural expression of hypomania: a case series. Prog Neuropsychopharmacol Biol Psychiatry 2004;28(7):1201–1207. DOI: 10.1016/j.pnpbp. 2004.06.015.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.