Tuberous sclerosis (TS) is a rare disorder of genetic origin, caused by mutations in the genes TSC1 and TSC2. It is characterized by benign tumors with multisystem involvement resulting in dermatological, nephrological, neurological and psychiatric manifestations. We are presenting a case of a 21 years old male with tuberous sclerosis presenting with dermatological manifestations, seizures, intellectual disability and psychiatric manifestations including delusions and hallucinations, developing extrapyramidal symptoms after antipsychotic administration. Neuroimaging showed characteristic subependymal calcified nodules. With appropriate anticonvulsant and antipsychotic medications he showed clinical improvement.
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