Citation Information :
Singh KM, Khakha RR, Khanande RV. Antioxidants Used in the Treatment of Various Psychiatric Disorders. Ind J Priv Psychiatry 2018; 12 (2):50-54.
Aim: To review the place of antioxidants in the treatment of psychiatric disorders, and to weigh it against the criticism for such treatments.
Background: Oxidative stress leads to aging, and antioxidant use (naturally available in food and supplementations) is one of the dietary modality for health promotion with major benefits. Antioxidants have also been used in treatment and prevention of many medical disorders. Brain, one organ using oxygen abundantly, and for its high lipid content suffers from oxidative stress. Even postmortem studies of brains of individuals with psychiatric disorders show degenerative changes possibly due to long-term damage by oxidative stress. Hence, the use of antioxidants in treating psychiatric disorders is one of the new areas of research in psychiatry.
Review results: Many agents have been used in the treatment of psychiatric disorders. Gingko biloba, Selegiline, omega- 3-triglycerides, vitamin E, and N-acetyl cysteine have been found useful as adjuncts in the treatment of schizophrenia. Similarly, the usefulness of adjunct N-acetyl cysteine and ethyleicosapentaenoic acid (EPA) treatment in bipolar depression is reported. omega-3-triglycerides have also been used in the treatment of dementia as an adjunct with mixed results. Ubiquinol has shown promise in treating autism.
Conclusion: The results of adjunct antioxidant treatment in psychiatry have been mixed with at times conflicting results. Much research is required to establish their place as a treatment modality in psychiatry.
Clinical significance: Use of antioxidants in the treatment of psychiatric disorders, at Max, currently, is of adjunct value only; even the cost-effectiveness of such treatments has to weighed against the useful clinical utility.
Jungerman T, Rabinowitz D, Klein E. Deprenyl augmentation for treating negative symptoms of schizophrenia: a doubleblind, controlled study. J Clin Psychopharmacol. 1999;19: 522-525.
Zhang XY, Tan YL, Cao LY, Wu GY, Xu Q, Shen Y, et al. Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics. Schizophrenia research. 2006 Jan 31;81(2-3):291-300.
Arvindakshan M, Ghate M, Ranjekar PK, Evans DR, Mahadik SP. Supplementation with a combination of ù-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr res. 2003;62:195-204.
Dakhale GN, Khanzode SD, Khanzode SS, Saoji A. Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia. Psychopharmacology. 2005;182:494-498.
Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, et.al. N-acetyl cysteine as a glutathione precursor for schizophrenia– a double-blind, randomized, placebo-controlled trial. Biol Psychiatry. 2008;64:361-368.
Berger G, Dell'Olio M, Amminger P, Cornblatt B, Phillips L, Yung A, et.al. Neuroprotection in emerging psychotic disorders. Early Intervention in Psychiatry. 2007;1:114-127.
Gvozdjakova A, Kucharska J, Ostatnikova D, Babinska K, Nakladal D, Crane FL. Ubiquinol Improves Symptoms in Children with Autism. Oxid Med Cell Longev. 2014;1-6.
Peet M, Horrobin DF. A dose-ranging exploratory study of the effects of ethyl- eicosapentaenoate in patients with persistent schizophrenic symptoms. J. Psychiatr Res. 2002;36: 7-18.
Forlenza MJ, Miller GE. Increased serum levels of 8-hydroxy-2-deoxyguanosine in clinical depression. Psychosom Med. 2006;68:1-7.
Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R. Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Report. 2003;8:365-370.
Van Hunsel F, Wauters A, Vandoolaeghe E, Neels H, Demedts P, Maes M. Lower total serum protein, albumin, and beta-and gamma- globulin in major and treatment-resistant depression: effects of antidepressant treatments. Psychiatry research. 1996;65:159-169.
Korpi ER, Wyatt RJ. Reduced haloperidol: effects on striatal dopamine metabolism and conversion to haloperidol in the rat. Psychopharmacology 1984;83:34-37.
Gilca M, Piriu G, Gaman L, Delia C, Iosif L, Atanasiu V, et.al. A study of antioxidant activity in patients with schizophrenia taking atypical antipsychotics. Psychopharmacology 2014; 231:4703-4710.
Khairova R, Pawar R, Salvadore G, Juruena MF, De Sousa RT, Soeiro-De-Souza MG. et.al. Effects of lithium on oxidative stress parameters in healthy subjects. Molecular medicine reports 2012;5:680-682.
Andreazza AC, Cassini C, Rosa AR, Leite MC, de Almeida LM, Nardin P, et. al. Serum S100B and antioxidant enzymes in bipolar patients. J Psychiatr Res 2007;41:523-529.
Amminger GP, Schäfer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM. et al. Long-chain–3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebocontrolled trial. Arch Gen Psychiatry 2010; 67:146-154.
Chandon P, Wansink B. Is Food Marketing Making us Fat? A Multi-disciplinary Review, Faculty and research working paper, Foundations and Trends® in Marketing, 2011, Now Publishers.