Indian Journal of Private Psychiatry

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VOLUME 11 , ISSUE 2 ( July-December, 2017 ) > List of Articles


Use of Pupillometry in Dementia: A Review of Published Literature

Citation Information : Use of Pupillometry in Dementia: A Review of Published Literature. Ind J Priv Psychiatry 2017; 11 (2):26-31.

DOI: 10.5005/jp-journals-10067-0006

License: CC BY-ND 3.0

Published Online: 01-04-2013

Copyright Statement:  Copyright © 2017; The Author(s).


Introduction: Diagnosis of Alzheimer's disease is based on clinical symptomatology supplemented with neuroimaging findings. While there are invasive techniques like lumbar puncture and expensive techniques like positron emission tomography/ single photon emission computed tomography (PET)/SPECT imaging available for diagnosis, none of these are totally accurate. Thus, there is a need for a cheap and noninvasive technique for diagnosing Alzheimer's dementia. Pupillary light reaction or pupillometry is one such technique based on the hypothesis that the pupillary size and reaction are governed by the cholinergic system of the brain, which is deficient in Alzheimer's dementia. A review of the studies showed that pupillary measures have been studied in patients with or without mydriatic/miotic agents and in those receiving anticholinergic esterase medications. These studies are discussed in detail in this review.

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